PD modeling question
From:From: "Hu, Chuanpu"
Subject:[NMusers] PD modeling question
Date:Wed, February 27, 2002 10:24 am
Hello,
I am looking for suggestions for modeling the time course for the following
type of effect. The rate of onset of the drug effect is believed to be much
faster than the rate of offset, suggesting nonlinear mechanism. This may be
consistent with covalent binding and receptor turnover, or some homeostatic
mechanism. The exact mechanism of action is not well understood, and I am
looking for empirical, hopefully physiologically plausible PD models to link
predicted (imputed) plasma concentration levels to drug effect.
Any help would be appreciated.
Chuanpu
----------------------------------------------------------------
Chuanpu Hu, Ph.D.
Modeling and Simulation, U.S.
GlaxoSmithKline
Tel: 919-483-8205
Fax: 919-483-6380