NONMEM Zoo

From: Nick Holford <n.holford@auckland.ac.nz> Subject: [NMusers] NONMEM Zoo Date: Sat, 03 Nov 2001 08:06:52 +1300 Leonid Gibiansky wrote: > > I think you can find any animal or plant in the NONMEM zoo An excellent point. It is useful to reflect when one feels that one has been bitten by a NONMEM bug that perhaps it is was a wise elephant bellowing in your ear to make you wake up and appreciate that a deeper issue needs to be considered. On a historical note users should be thankful that one can now estimate F1 with a zero-order input. Early versions of NONMEM assumed that a zero-order input must mean a fully bioavailable parenteral input. This feature/bug bit me on the first PK problem I ever tried with NONMEM and put me off using it for some years. Nick -- Nick Holford, Divn Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.htm