FW: DURATION data item (instead of the RATE data item)

From: "Bachman, William" <bachmanw@globomax.com> Subject: [NMusers] FW: DURATION data item (instead of the RATE data item) Date: Fri, 2 Nov 2001 13:23:01 -0500 Pierre Maitre writes: >In brief, I have a known amount of drug, a known rate of administration, >a known duration of administration, and I just would like to calculate >the bioavailability of a continuous sub-cutaneous infusion with ADVAN4. >If I could use a DURATION data item (instead of the RATE data item), >this would solve my problem, but there is no such animal in the NONMEM >zoo. Moreover, I do not intend to use the D1 parameter and estimate the >duration, because duration is a data that was precisely measured. > >Has anyone had this problem, and how was it solved? See PREDPP Guide page 26, for a discussion of one technique using a modeled rate to get exactly what you want. Another technique is to use a modeled duration and set it equal to the duration data item (disguised as another type of data item). Stuart Beal