Re: Non-zero peripheral drug amount

From: Nick Holford <n.holford@auckland.ac.nz> Subject: Re: Non-zero peripheral drug amount Date: Wed, 03 Oct 2001 10:18:54 +1200 Paul, You should have noticed this WARNING from NM-TRAN: (WARNING 48) DES-DEFINED ITEMS ARE COMPUTED ONLY WHEN EVENT TIME INCREASES. E.G., DISPLAYED VALUES ASSOCIATED WITH THE FIRST EVENT RECORD OF AN INDIVIDUAL RECORD ARE COMPUTED WITH (THE LAST ADVANCE TO) AN EVENT TIME OF THE PRIOR INDIVIDUAL RECORD. When you save X2 in the TABLE file NONMEM is getting the value from the last time of the previous individual record. A cleaner way of getting the amount in A(2) is to obtain it in $ERROR e.g. X2=A(2) This value will be guaranteed to be the solution of DADT(2) at TIME=0 for that individual. There is also no need to use $DES. You can use ADVAN3 and get the amount in compartment 2 in $ERROR from the A(2) array as I have indicated above. BTW Where did you get the formula you use for BSA? This is not the usual duBois and duBois formula. > BSA=(HT*WGT/3600)**0.5; CALCULATES BSA Nick -- Nick Holford, Divn Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.htm