RE: Pharmacokinetics, allometry and flat earth theories
From: "Piotrovskij, Vladimir
[JanBe]" <VPIOTROV@janbe.jnj.com>
Subject: RE: Pharmacokinetics, allometry and flat earth theories
Date: Mon, 15 Oct 2001 10:15:08 +0200
I totally agree with Nick and Paul that using BSA for dose scaling has
no
scientific rationale. Though I am not sure using a factor of WT^0.75
in dose
calculation is really necessary in adult population, BSA scaling should
be
certainly avoided as it may result in wrong individual dose prescription.
Best regards,
Vladimir
------------------------------------------------------------------------
Vladimir Piotrovsky, Ph.D.
Research Fellow
Advanced Modelling and Simulations
Global Clinical Pharmacokinetics and Clinical Pharmacology (ext. 5463)
Janssen Research Foundation
B-2340 Beerse
Belgium