Re: Integrator options

From: "Sam Liao" <sliao@pharmaxresearch.com> Subject: Re: Integrator options Date: Sun, 14 Oct 2001 18:16:53 -0400 Hi Atul: You will not have this knid of problem if you switch to NONMEM. This is typical problem when you are working with disease progression in which you have DE intgration over a long period of time. In my expereience, both NONMEM and WinNonMix can handle this very well. "You can try ADVAN8 and/or ADVAN9 instead of ADVAN6; either of these is better able to handle stiff systems of differential equations." quoted from Alison (NONMEM usersnet archive) Best regards, Sam Liao, Ph.D. PharMax Research 270 Kerry Lane, Blue Bell, PA 19422 phone: 215-6541151 efax: 1-720-2946783