RE: Post treatment effect

From: "Stephen Duffull" <sduffull@pharmacy.uq.edu.au> Subject: RE: Post treatment effect Date: Thu, 11 Oct 2001 08:32:58 +1000 Atul In addition to Nick's comment about the changing underlying disease process you might also consider that the temporal nature of the "drug on" model is not the same as the "drug off" model, eg the time for maximum effect of a proton pump inhibitor is a few hours but the time to loss of effect is a few days. There are also examples where the off is faster than the on. In addition some feedback mechanisms may take longer to return to "normal" than the length of your experiment and therefore apparently altering the baseline... etc etc ... Regards Steve ================= Stephen Duffull School of Pharmacy University of Queensland Brisbane, QLD 4072 Australia Ph +61 7 3365 8808 Fax +61 7 3365 1688 http://www.uq.edu.au/pharmacy/duffull.htm