Re: Post treatment effect

From: Nick Holford <n.holford@auckland.ac.nz> Subject: Re: Post treatment effect Date: Wed, 10 Oct 2001 16:58:56 +1300 Atul, If I understand you correctly you are wanting to describe the situation where the response after treatment is different from the starting response. The response (what you call "levels") may have its own time course independent of drug treatment or the time course may be affected by the treatment. This sounds like you might want to consider a disease progress model that accounts for the changing response over time. This review may help: Chan PLS, Holford NHG. Drug treatment effects on disease progression. Ann Rev Pharmacol 2001;41:625-59 Nick -- Nick Holford, Divn Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.htm