logistic regression

From: "Charlotte van Kesteren" <Apcks@slz.nl> Subject: logistic regression Date: Fri, 14 Sep 2001 16:14:58 +0200 Dear NONMEM-users, We have AUC-values and toxicity data of a total of 143 individuals, originating from 4 studies with different treatment schedules. The toxicity data are dichotomous, i.e. the adverse effect either occurs (1) or it does not (0). We have one data point for each patient. With logistic regression in NONMEM, we have tried to model the relation between exposure and the chance of toxicity. Furthermore, we want to investigate a possible schedule dependency in this relation. However, we are not sure whether it is appropriate to estimate interindividual variability with logistic regression with only one observation per individual. Furthermore, how can we judge goodness of fit with such a data set? Does anyone have experience with these kind analyses? Thank you in advance for your help. Best regards, Charlotte van Kesteren