AW: Conversion of micro constants to macro constants

From: Lutz.Harnisch@aventis.com Subject: AW: Conversion of micro constants to macro constants Date: Wed, 15 Aug 2001 10:23:52 +0200 The lambdas (alpha, beta, gamma) can numerically be calculated by evaluating the Eigenvalues from the Eigenmatrix. The Eigenmatrix is constructed from the linear DES. See Splus guide on eigen() for references. The special case for an example of a mammilary model is given below as Splus code, but any other linear DES could be handled in equivalently. ____________________________________ k10 <- 1.486 k12 <- 0.351 k21 <- 0.080 k13 <- 1.703 k31 <- 0.633 print(c(k10, k12, k21, k13, k31)) dg <- matrix(NA,3,3) dg[1, ] <- c( - k10 - k12 - k13, k21, k31) dg[2, ] <- c( k12 , - k21, 0) dg[3, ] <- c( k13, 0, - k31) print(dg) print(-eigen(dg)$values) _____________________________________ Lutz Harnisch DMPK PopKin Aventis Pharma Frankfurt Germany