Pred vs Wres
From: "Ferrin Harrison 301-827-3213 FAX 301-480-2825" <HARRISONF@cder.fda.gov>
Subject: Pred vs Wres
Date: Fri, 27 Jul 2001 16:23:26 -0400 (EDT)
What models for an entry compartment would conceal a downstream compartment?
In particular, could the SR rate be sufficiently slow to conceal one of the IV
compartments, rendering one compartment comparable to infinite rate of
elimination or equilibration?
By conceal I mean render difficult or impossible to estimate for the data
available. I can't conceive of an entry compartment mathematically neutralizing
a downstream compartment.