Characters in error are: FWORK

From: "Dr. Olaf Kuhlmann" <olaf.kuhlmann@medizin.uni-halle.de> Subject: Characters in error are: FWORK Date: Mon, 18 Jun 2001 12:02:48 +0000 Dear nmusers, I am a beginner in using NONMEM and have some problems modeling my PK PD data (ADVAN 3). I have 59 subjects, for each subject 2-3 plasma data at different time points, in total 153 records( and 10 data items). During the run the following message arises: "an error was found in the control statements. The characters in error are: FWORK. 36 ERROR has occurred while creating required files" (two computers tried, same result) --> the error did not arise when I omit the first/or last 20 subjects. Is there a limitation in no. of data records? (chapter 6, page 50 of the introductory says NO). --> second question (for my better understanding). When I omit the first (or last) 20 subjects, and everything is fine until the output file, I find in this file in the line: No. of Data Recs in data set: --> the number 98 but some lines later: Tot. No. of OBS Recs: --> just the number 63 (which is the correct number in my data file) What is the reason for this difference? Please help me... Thanks a lot in advance OLAF ***************************************************************** Dr.rer.nat. Olaf Kuhlmann (Dipl.-Biol.) Martin-Luther-Universitaet Halle-Wittenberg Medizinische Fakultaet Institut fuer Pharmakologie und Toxikologie Sektion Pharmakokinetik Magdeburger Str. 4 06097 Halle/Germany Tel.: 0345-5574091 FAX : 0345-5571835 E-mail: olaf.kuhlmann@medizin.uni-halle.de Webpage: http://www.medizin.uni-halle.de/pharmakin/Kuhlmann.htm *****************************************************************