RE: parent drug & metabolite

From: "Bachman, William" <bachmanw@globomax.com> Subject: RE: parent drug & metabolite Date: Tue, 24 Apr 2001 09:45:32 -0400 Most likely, you will define your parent-metabolite model either via differential equations, ADVANs 6,8, or 9, or by using general linear models, ADVANS 5 or 7. Your model will determine the appropriate CMT to use for for doses, parent observations and metabolite observations. e.g. CMT=1 for dose records of parent drug to the oral depot, CMT=2 for parent observations in a central compartment (defined by your model), and CMT=whatever, depending on how the metabolite compartment is defined in your model (not necessarily CMT=2). Regarding the dose of metabolite, if modeling parent and metabolite simultaneously, you may have to assume all parent is converted to metabolite (unless you have additional info, like parent concentrations in urine, etc.), otherwise you may have an identifiability problem. Bill