Re: problem with AUC

From: "Rik Schoemaker" <RS@chdr.nl> Subject: Re: problem with AUC Date: Thu, 19 Apr 2001 12:42:31 +0200 Dear Brunhild, If you only have oral data then the parameter you estimate is Cl/F and AUC is simply given by AUC=3DDose/(Cl/F); the problem is not in estimating AUC without knowing bioavailability but rather in finding out what Cl is... As far as comparing objective functions between method 0 and 1 is concerned: you should never do it. It provides no indication whether one is preferable over the other; it is like comparing apples to pears because they provide different approximations to the model you're trying to estimate. This does not mean that in practice they cannot be similar, but this should not guide you. My advice: if method 1 converges then use method 1 (always, at least for your final model). Kind regards, Rik Schoemaker Rik C. Schoemaker, PhD Biostatistician - pharmacokineticist Centre for Human Drug Research (CHDR) Zernikedreef 10, 2333CL Leiden, Netherlands tel +31 (0) 71 5246417; fax +31 (0) 71 5246499 email rs@chdr.nl; http://www.chdr.nl