problem with AUC

From: onkpharm <onkpharm@uni-muenster.de> Subject: problem with AUC Date: Tue, 17 Apr 2001 12:48:40 +0200 Hello everybody, I am a new NONMEM-user and trying to model data from 20 children receiving high-dose busulfan orally over 4 days every 6 hours. I'm using a one compartment-model (ADVAN2 TRANS2) with IOV (interoccasional variability) on Cl; furthermore, I included ETAS on Cl, V and ka and I use BSA as a covariate for Cl and V. My questions are as follows: 1. How can I determine the AUC (Area under Curve from 0 to infinity) when the bioavailability is unknown? Does anybody know a possibility? 2. There are 349 plasma samples from 147 administrations; I thought this would be enough data to use Method=1 as estimation method. But I get a smaller objective function when using Method=0. Is this normal with these many data points? Thanks in advance for your help, Brunhild Schiltmeyer, R. Ph. Department of Pediatric Oncology University of Muenster, Germany