Re: Bootstrap resampling!

From: "Paul Williams" <pwilliams@uop.edu> Subject: Re: Bootstrap resampling! Date: Fri, 23 Mar 2001 07:59:07 -0800 If I am understanding you correctly, you have two choices, 1] take ALL the subjects data [including the concentrations] and copy and paste into the bootstrap data set or 2] bootstrap the weighted residuals. If you choose option 1 you would have to take all the subjects data including dose and concentration history, covariates, etc and copy [ie resample with replacement] into the bootstrap data set. It would not make sense to take the concentrations from a 100 kg individual and assign them to a 50 kg individual especially if clearance or volume were related to size. How are you using the bootstrap? Are you using the less synthetic percentile bootstrap, are you bias correcting your original estimates and are you using the bootstrap to internally validate the model? Cheers! Paul Williams