RE: Covariate: statistical vs clinical

From: Vladimir Piotrovskij Date: January 23, 2001 technical Source: cognigencorp.com
From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com> Subject: RE: Covariate: statistical vs clinical Date: Tue, 23 Jan 2001 09:52:29 +0100 Atul, 1. In the drug development context, a fixed effect of a covariate is clinically relevant if it changes prescription recommendations (e.g., dosing per kg body weight instead of an identical dose for everyone, or different doses for males and females, etc.) 2. I don't think there is a universal answer to this question: it depends on your specific situation. Concomitant medication issues are perhaps most complicated. Best regards, Vladimir ---------------------------------------------------------------------- Vladimir Piotrovsky, Ph.D. Janssen Research Foundation Human Pharmacokinetics (ext. 5463) B-2340 Beerse Belgium Email: vpiotrov@janbe.jnj.com

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Jan 19, 2001 Atul Bhattaram Venkatesh Covariate: statistical vs clinical
Jan 23, 2001 Vladimir Piotrovskij RE: Covariate: statistical vs clinical
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