Re: 95% CI of paramter estimate

From: "Jogarao Gobburu 301-594-5354 FAX 301-480-3212" <GOBBURUJ@cder.fda.gov> Subject: Re: 95% CI of paramter estimate Date: Mon, 13 Nov 2000 17:26:50 -0500 (EST) Hello, Bootstrap is another technique that is used to obtain SE of the point estimates. Few references: 1. Parke J, Holford NH, Charles BG. A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models. Comput Methods Programs Biomed. 1999 Apr;59(1):19-29. 2. Jonsson EN, Karlsson MO. Xpose--an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM. Comput Methods Programs Biomed. 1999 Jan;58(1):51-64. Regards, Joga Joga Gobburu Pharmacometrics, CDER, FDA.