Caution with verbatim code/RE: Number of evaluations of differential equations

From: "Gastonguay, Marc" <gastonguaym@globomax.com> Subject: Caution with verbatim code/RE: Number of evaluations of differential equations Date: Thu, 24 Aug 2000 15:41:11 -0400 Dear Phil, Not too long ago, you indicated that you ran into the following error message with a differential equation model: NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE. MAXIMUM NO. OF EVALUATIONS OF DIFFERENTIAL EQUATIONS,100000, EXCEEDED You also said that your attempt to increase the maximum number of evaluations with some verbatim code did not work (from your message): "FIRST " COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5 " INTEGER IDUM1,IDUM2,IMAX,IDUM4,IDUM5 " IMAX=1000000 I responded, in part, by incorrectly suggesting that there might be a hard-coded limit that was not affected by your verbatim code. In fact, Alison Boeckmann says that several users have implemented this code without a problem. One possibility, though, is that the code has not been entered correctly in your control stream. The problem that other users have encountered when trying to implement this (and possibly other) verbatim code involves a single missed space. If the line in A.(below) is mistakenly entered without a space between the quote and the C in COMMON (as in B. below), NMTRAN recognizes this line of verbatim code as a FORTRAN comment and the COMMON statement is ignored. A. " COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5 B. "COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5 FYI: The original code cited in http://huxley.phor.com/nonmem/nm/98oct071998.html http://huxley.phor.com/nonmem/nm/98oct071998.html is correct, but subsequent reiterations of this verbatim code to nmusers may have omitted this important space. Hope this helps. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Marc R. Gastonguay, Ph.D Manager, Pharmacometric R&D GloboMax LLC 7250 Parkway Drive, Suite 430 Hanover, MD 21076 Tel: 410.782.2224 Fax: 410.712.0737 email: gastonguaym@globomax.com