Re: weighting observed data
From: j.dejongh@lapp.nl
Date: Mon, 5 Jun 2000 14:14:54 +0200
Subject: Re: weighting observed data
Dear Francesca,
What kind of error model did you use ? proportional or constant/additive?
If the concentrations in plasma differ very much from those in the dialysate and you want to fit both types of data with a single residual error, I would prefer a proportional error model anyway.
If you prefer to use separate error weighting for plasma and dialysate for whatever reason (e.g. known differences in assay sensitivity), I would introduce a true/false variable to discriminate between the two DV's.
Hope this helps,
let me know if you want a more specific example of the code.
Dr. Joost DeJongh
Leiden Advanced Pharmacokinetics & Pharmacodynamics (LAP&P) Consultants
Archimedesweg 31
2333 CM Leiden
The Netherlands
Phone: + 71 524 3000
Phone: + 71 524 3002 (direct line)
fax: + 71 524 3001