Re: design of PK experiment

From: "Stephen Duffull" <sduffull@hotmail.com> Subject: Re: design of PK experiment Date: Tue, 13 Jun 2000 16:26:32 BST Hi Alison An alternative method for designing a population PK experiment would be via assessment of the population Fisher information matrix. A variety of different designs could be evaluated relatively quickly and the best design (based on say the required precision of the parameter estimates) chosen. The design therefore can be based on a number of factors such as the total number of blood samples, the desirable maximum number of patients, the number and timing of blood samples per patient. Evaluation of the population Fisher information matrix would be much more efficient that performing simulation (especially when 200 simulations may be needed per design). A theoretic approach has been developed for evaluation of the matrix and is available via: http://hermes.biomath.jussieu.fr/pfim.htm or you could contact one of the authors: Sylvie Retout (retout@biomath.jussieu.fr) Steve Duffull (sduffull@pharmacy.uq.edu.au) France Mentre (mentre@biomath.jussieu.fr) Hope this helps Steve ============= Stephen Duffull School of Pharmacy University of Queensland Brisbane QLD 4072 AUSTRALIA Ph +61 7 3365 8808 Fax +61 7 3365 1688