RE: problem advan4 trans4

From: "Sreenivasa Rao Vanapalli" <rao@pharm.cpb.uokhsc.edu> Subject: RE: problem advan4 trans4 Date: Thu, 18 May 2000 10:07:10 -0700 I don't know how far I'm right about my suggestion. But i had the same problem with two compartment first order oral abosrption. I did not calculate CL as parameter so I used ADVAN4. With my meagre knowledge I can add my own words to this problem. As you mentioned you had problem with V3, KA, F2, ALAG2. The problem is with declaring your parameters in the control file. Why did you chose to reparameterize V3 with S3 (S3=V3). Just leave V3 as it is. Next, if you check the NONMEM manual I think volume V, you will find what parameters can be calculated with ADVAN4 TRANS4. Because this does not support F2 and ALAG2 (so does't calculate). Next with KA, try reparameterizing KA=KA and see if that solves your problem. I'm a graduate student learnng alphabets in NONMEM. Please advice me if I'm wrong. Sreenivasa Rao Vanapalli College of Pharmacy University of Oklahoma health Sciences center Oklahoma city, OK-73106