problem advan4 trans4

From: Miguel Alexandre Soares <miguel.a.soares@netc.pt> Subject: problem advan4 trans4 Date: Thu, 18 May 2000 13:33:09 +0200 Dear group I am using the input file bellow to model the clinical data of a drug that is known to be well described by a two compartment model with oral absorption. After analyze the output file, I noticed that NONMEM didn't change V3, Ka, F2 and ALAG2. I tried other models but was unable to solve the problem. Could someone help me to find where the problem is? $PROBLEM CCA $INPUT ID,DAT1=DROP,TIME,Dose=AMT,Cp=DV,Sex,Wt,Ht,SCr,Age,TrA,BSA,CrCL,LBW $DATA ..\temp\CCA1.CSV WIDE IGNORE=I $SUBROUTINE ADVAN4 TRANS4 $PK TCL=THETA(1) TV2=THETA(2) d# TQ=THETA(3) TV3=THETA(4) TKA=THETA(5) CL=TCL+ETA(1) V2=TV2+ETA(2) Q=TQ V3=TV3 KA=TKA+ETA(3) K=CL/V2 K23=Q/V2 K32=Q/V3 S2=V2 S3=V3 F2=THETA(7) ALAG2=THETA(6) $ERROR Y=F+EPS(1) $THETA (0,10,) (0,90,) (0,25,) (0,170,) (0,2,) (0,0.1,) (0,.6,1) $OMEGA DIAGONAL(3) 0.30 0.67 0.25 $SIGMA DIAGONAL(1) 0.40 $ESTIMATION MAXEVAL=9000 POSTHOC SIGDIGITS=3 PRINT=5 $COVARIANCE $TABLE ID CL Q V2 V3 KA ETA(1) ETA(2) FILE=TABELA.TXT NOPRINT ONEHEADER $SCAT DV VS PRED UNIT $SCAT DV VS RES ORD0 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Dr. Miguel Alexandre Soares Instituto Superior Ciências da Saúde - Sul Campus Universitário Quinta da Granja 2825 Monte da Caparica - Portugal e-mail: miguel.a.soares@netc.pt ~~~~~~~~~~~~~~~~~~~~~~~~~~~~