ADVAN4!!!

From: "Sreenivasa Rao Vanapalli" <rao@pharm.cpb.uokhsc.edu> Subject: ADVAN4!!! Date: Fri, 10 Mar 2000 14:56:55 -0800 Hi everyone I would like to ask a question. I'm trying to model population data for promethazine in rats using two compartment model. With nonmem I'm using subroutine "ADVAN4" for this model. And I'm getting trouble with this. The error message I'm getting is " PK PARAMETER FOR K IS NON-POSITIVE" Control statement I'm using is $INPUT ID DOSE=AMT TIME CP=DV WT $DATA IMPMZ $SUBROUTINES ADVAN4 $PK KA=THETA(1)*ETA(1) K23=THETA(2)*ETA(2) K32=THETA(3)*ETA(3) K=THETA(4)*ETA(4) V=THETA(5)*ETA(5) $ERROR Y=F*(1+ERR(1)) $THETA (0,5)(0,.8)(0,.2)(0,.1)(0,.8) $OMEGA BLOCK(5) 1.6 5 22.5 3.74 15 11 0.2 2 1.7 1.2 1.6 8.5 6.3 2.3 5.72 $SIGMA .2 $ESTIMATION MAXEVAL=500 PRINT=5 $COVR $TABLE ID DOSE WT TIME $SCAT CP VS TIME $SCAT PRED VS TIME $SCAT (RES WRES) VS TIME BY ID $SCAT PRED VS CP UNIT Data I'm using is. 1 .5 . . .35 1 . .033 .149 . 1 . .515 .262 . 1 . 1.992 .163 . 2 .5 . . .365 2 . .083 .24 . 2 . .769 .247 . 2 . 3.017 .156 . 3 .5 . . .37 3 . .167 .284 . 3 . 1.004 .188 . 3 . 4.021 .09 . 4 .5 . . .365 4 . .271 .256 . 4 . 1.51 .18 . 4 . 5.942 .102 . 9 .5 . . .31 9 . .033 .168 . 9 . .514 .198 . 9 . 2.031 .147 . 10 .5 . . .315 10 . .083 .209 . 10 . .767 .201 . 10 . 2.986 .119 . 11 .5 . . .32 11 . .167 .245 . 11 . 1.172 .165 . 11 . 3.983 .105 . 12 .5 . . .315 12 . .261 .251 . 12 . 1.538 .17 . 13 .5 . . .37 13 . .033 .158 . 13 . .506 .232 . 13 . 2.01 .221 . 14 .5 . . .385 14 . .083 .257 . 14 . .754 .2 . 14 . 3. .149 . 15 .5 . . .39 15 . .167 .273 . 15 . 1. .198 . 15 . 4.075 .096 . 16 .5 . . .38 16 . .249 .224 . 16 . 1.488 .147 . 16 . 6.125 .066 . Can anyone help me in this.. thanks Sreenivasa Rao Vanapalli College of Pharmacy, University of oklahoma Health Sciences Center 1110 N.Stonewall Oklahoma City, OK-73117 Tel:405-271-6484 Extn:47232 (office) :405-521-0826 (Home) Fax: 405-271-7505(Office)