ADVAN3 TRANS3 Problem

From: HARRY.MAGER.HM@bayer-ag.de Subject: ADVAN3 TRANS3 Problem Date: Sat, 6 Nov 1999 10:21:46 +0100 Dear colleague, further to modelling vancomycin and gentamycin pharmacokinetics I would like to draw your attention to the USC-Pack, developed at the University of Southern California by R. Jelliffe, A. Schumitzky and many others. It has got implemented population pharmacokinetic models of these and other drugs from this class, compared to NONMEM, learning to handle the programme takes much less time and it has got an added advantage that cannot be overestimated: it uses the nonparametric NPEM algorithm in the fitting process. Consequently, (often unrealistic) assumptions usually imposed on the distribution of e.g. individual pharmacokinetic parameters are not necessary. For more detailed information you can contact Roger W. Jelliffe, M.D. Professor of Medicine, USC USC Laboratory of Applied Pharmacokinetics 2250 Alcazar St, Los Angeles CA 90033, USA Phone (323)442-1300, fax (323)442-1302, email= jelliffe@hsc.usc.edu Web site= http://www.usc.edu/hsc/lab_apk. So far, we have made some comparison studies and we are very satisfied with the nonparametric approach, which may be considered at least a valuable additional tool in population pharmacokinetic modelling and clinical trial simulation. Harry Mager Bayer AG Clinical Pharmacology D-42096 Wuppertal Phone: 0049-202-368891 E Mail: Harry.Mager.HM@Bayer-Ag.de