ADVAN3 TRANS3 Problem Solved

From: Rebecca Wrishko <wrishko@unixg.ubc.ca> Subject: ADVAN3 TRANS3 Problem Solved Date: Thu, 04 Nov 1999 14:04:02 -0800 Thank you to everyone who expeditously responsed to the above mentioned problem. Setting VSS=V+THETA(3) permitted the NONMEM execution to provide estimates of CL, V AND VSS whereby VSS>V. Just for clarification, when VSS=THETA(3) does the routine define the variable as volume of peripheral compartment (VSS-V) rather than generating estimates of VSS? Also, Dr. Sheiner wrote that TVVSS (typical value) is Theta(3) + Theta (4), does this suggest that the TVVSS is the sum of a volume and intercompartmental clearance terms (VSS+Q), or the sum of a volume and a slope (ie. VSS*WT)? Again, thank you for your assistance. Rebecca Wrishko Division of Clinical Pharmacy Faculty of Pharmaceutical Sciences University of British Columbia Vancouver, British Columbia, Canada Email: wrishko@unixg.ubc.ca