Pharsight to NONMEM, simulations and modeling

Date: Wed, 24 Nov 1999 16:14:43 -0800 From: Jeff Wald <jwald@pharsight.com> Subject: Pharsight to NONMEM, simulations and modeling There has been discussion over the past week regarding Pharsight Trial Designer (PTD) and NONMEM. In a previous message I addressed the question regarding whether the two packages provide similar results. However, I failed to clear up confusion regarding the translation between the two formats. In the following note I will give examples of equivalent NONMEM and WinNonMix models and the corresponding PTD model. The model is a simple case that was used as part of our internal testing of WinNonMix. I will provide a summary below. I have also included a summary of NONMEM and WinNonMix results when both programs were used to analyze simulated results. The model (PTD.mdl): One Compartment model with First Order Absorption Exponential error on structural model parameters Proportional residual error variance model Simulate 100 replicates of trial using PTD Each trial has 100 subjects Each subject has 6 PK samples collected No error in sampling times Simulated parameter values are provided in the attached table. NONMEM: (control.txt) WinNonMix: WNM.txt (Please note, the easiest way to present the WinNonMix model to the general audience was to show a summary ASCII file. However, the inputs to WinNonMix are made through the program's graphical user interface.) Summary: (N0.pdf) This file contains a table that shows input parameter values for the model and the average values obtained by different methods (First order and conditional first order estimation) in NONMEM and WinNonMix for 100 replicate simulations. I have eliminated much of the granularity regarding the process, but if parties are interested in the testing of WinNonMix please contact me directly or send a note to support@pharsight.com. Regards, Jeff