RE: IOV effects

From: Vladimir Piotrovskij Date: November 23, 1999 technical Source: cognigencorp.com
From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com> Subject: RE: IOV effects Date: Tue, 23 Nov 1999 15:52:36 +0100 It is the question of study design. If you are going to estimate IOV separately and independently from IIV you should design your study accordingly. In case you have only a small proportion of subjects tested at different occasions mixed-effects modelling will not help you irrespective to the program you use (NONMEM, nlme, a new SAS PROC (I forgot the name), etc.). Vladimir ---------------------------------------------------------------------- Vladimir Piotrovsky, Ph.D. Janssen Research Foundation Clinical Pharmacokinetics B-2340 Beerse Belgium Email: vpiotrov@janbe.jnj.com

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Nov 23, 1999 James IOV effects (inter-occasion variability)
Nov 23, 1999 Mats Karlsson Re: IOV effects
Nov 23, 1999 Pascal Girard Re: IOV effects
Nov 23, 1999 James Re: IOV effects
Nov 23, 1999 Vladimir Piotrovskij RE: IOV effects
Nov 23, 1999 James RE: IOV effects
Nov 23, 1999 Mats Karlsson Re: IOV effects
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