Re: Dble exponential error model

From: "Steve Duffull" <sduffull@fs1.pa.man.ac.uk> Subject: Re: Dble exponential error model Date: Thu, 7 Jan 1999 09:53:45 GMT Hi Laurent > I need to calculate the Individual Weight residuals (IWRES) with a double > exponential intra-individual error model. It would seem to me that you should obtain the weighting the same as usual. Therefore W=F*EXP(EPS(1)) the rest of the error term "+THETA(10)*EXP(EPS(2))" is independent of the model predicted concentration and is constant for any given individual. Perhaps the question might be looked at in terms of, since "THETA(10)*EXP(EPS(2))" will always be positive should: IWRES=IRES/W-C where C=THETA(10)*EXP(EPS(2)) However I have 2 points: I do not understand why you would want to use this model. I do not understand how your model can identify the difference between THETA(10) and EPS(2). Regards Steve Stephen Duffull School of Pharmacy University of Manchester Ph +44 161 275 2355 Fx +44 161 275 2396