Re: Q:$DES with a lagged zero-order bolus dose

From: alison@c255.ucsf.EDU (ABoeckmann) Subject: Re: Q:$DES with a lagged zero-order bolus dose Date: 29 Jun 1998 18:30:39 -0400 With ADVAN6, dosing is handled the same as with ADVAN3 (or any other ADVAN routine). Include a dose record with the AMT and the RATE data items, setting RATE to -2. This indicates that D1 will be modelled in $PK, as was done. In the $DES block, code only the compartmental kinetics. PREDPP itself adds an extra term to DADT(1) giving the total rate of infusion into the compartment (in this case, AMT/D1) when appropriate: starting when time = ALAG1, and ending when the given AMT has been entered into the system. The $DES block should be simply: $DES DADT(1)=-(K12+K)*A(1) DADT(2)=K12*A(1)-K21*A(2) Alison Boeckmann