AW: Error trap

From: "Harnisch, Lutz, HMR/DE" <Lutz.Harnisch@hmrag.com> Subject: AW: Error trap Date: 19 Dec 1997 16:18:03 -0500 we use these alternatives: ADVAN3 TRANS4 CL = THETA(1) V1 = THETA(2) V2 = THETA(3) VSS = V1+V2 DVZ = THETA(4) VZ = V1 + V2 + DVZ Q = CL*(V2/DVZ) * (V2+DVZ)/VZ or ... V1 = THETA(2) VSS = THETA(3) V2 = VSS-V1 ... or if (V1<V2) ... V1 = THETA(2) DV2 = THETA(3) V2 = V1+DV2 VSS=V1+V2 ... but only the first and last one give always POSTHOC estimates. But therefore you have to recalculate the error/omega of VSS. The second method has the same difficulties with V1>VSS, its only for completeness. That's what we use, also to avoid the interpretation of Q itself, because Vz is more meaningful for our understanding. Best regards Lutz ______________________________ Lutz Harnisch Hoechst Marion Roussel Preclinical Development Pharmacokinetics Population Analysis an Modelling Building H840, Room 449 D-65926 Frankfurt/Main ------------------------------------------------------------ phone: +49 (69) 305-16481 fax: +49 (69) 305-81990 mailto:Lutz.Harnisch@hmrag.com