Error trap

From: "David Nix" <nix@pharmacy.arizona.edu> Subject: Error trap Date: 19 Dec 1997 15:43:52 -0500 In using Advan3/ Trans3 routines, it has been common to obtain the error V>Vss. This model is parameterized by: CL V Q - distributional clearance Vss with the following relationships: k10 = CL/V k12 = Q/V k21 = Q (Vss-V) The population estimates come out reasonable, but V>Vss for some individuals. As a result, the, the post hoc eta's are not obtained for anyone. I have got around this problem previously by parameterizing the model differently. Does anyone have and error trap or other method to avoid this problem which makes it possible to parameterize using Vss.