Another(?) ADVAN5 Problem

In any event, sorry, there are no 'settings' that will help ADVAN5. I presume that you all include the NOABORT option on the $ESTIMATION record so that NONMEM can back away from the "bad" thetas and try values closer to the last good set of thetas. Gary originally said: The problem we are facing is that when we run a simple 2 compartment model using advan5 the program ends even before the iteration process is invoked (the VAX gives a divide by zero error message in the DDDFRS routine line 23). David, are you trying Gary's problem on your Vax? If so, the fact that no divide by zero occured points to some problem with the installation on Gary's Vax. I suggest that PREDPP be read in from the original installation tape, and that Gary verify that the source code for ADVAN5, REXPON, and RXSUBS is exactly as read. Recompile them too. Another possibility is that Gary uses a different (later?) version of FORTRAN than David, or that he uses different compiler options. Gary might try compiling without optimization, for example.