Dear Kyun-Seop,
This highly depends on the type of problem one is interested in.
An acceleration from 10 min to 1 min for a 2-compartment model
will have very little impact on the total duration of a modeling project.
An acceleration from 10 months to 1 month may make the difference
whether or not a project / approach is feasible.
The popPKPD pograms for which I have seen/used parallelized versions
available are NPAG & NPEM, S-Adapt, NONMEM / Aspeed (see Dr Sale's
pdf link), and most recently WinBUGS (see ACOP 08 poster from
Metrum institute).
http://www.metrumrg.com/publications/acop_2008_winbugs.pdf
Best regards
Juergen
P.S.: I hope you recognize the ethical minimum of a population PK run
which should not decrease below a 3 min coffee break.
-----------------------------------------------
Jurgen Bulitta, PhD
Pharmacometrics
University at Buffalo, NY, USA
Phone: +1 716 645 2855 ext. 281
Fax: +1 716 645 3693
Email: jbulitta
-----------------------------------------------
-----Ursprngliche Nachricht-----
Von: "BAE, KYUN-SEOP" <KYUN-SEOP.BAE
Gesendet: 12.09.08 18:55:13
An: <nmusers
Betreff: [NMusers] What would the impact be, if NONMEM runs 10 times faster than now?
Dear NMusers,
I would like to ask the following question.
What would be the impact if NONMEM "single-run" runs 10 times faster
than now?
"Single-run" is used to contrast to the "multiple-run" of bootstrapping.
The reason I'm asking is to know how much valuable it is to pursue the
single-run speed.
Thanks,
==========Kyun-Seop Bae
Pfizer Global Research and Development - La Jolla
10777 Science Center Drive
San Diego, CA 92121
Office: 858-638-3757
Mobile: 858-212-6628
Email: kyun-seop.bae
kyunseop.bae