QSP modelling - At the heart of the action
Speaker: Nelleke Snelder, Senior Consultant, LAP&P Consultants, Leiden, The
Netherlands
Thursday, Nov 16, 2017, 12:00 pm to 1:00 pm EDT
Register at https://register.gotowebinar.com/register/3899274333265939713
Abstract:
PKPD modelling has developed from an empirical and descriptive approach into a
scientific discipline based on the (patho-) physiological mechanisms behind
PKPD relationships. As a result, PKPD models range from purely empirical
models, i.e. descriptive models to mechanism-based and Quantitative Systems
Pharmacology (QSP) models with an increasing level of complexity and increasing
level of predictive power. The preferred PK/PD modelling approach (i.e.
fit-for-purpose modelling) highly depends on the questions that need to be
answered in addition to what level of detail is required. Empirical and
mechanism-based models have already demonstrated their value in
drug-development and examples of the application of QSP models are emerging.
Application of QSP models, however, may be challenging as they are more complex
and require a larger amount of informative data. Moreover, combining different
types of information is essential for QSP approaches.
The questions for the modeller at hand are: (1) what knowledge is required to
answer the question, (2) how to select and integrate informative data, (3) how
to balance between complexity and quantifiability and (4) when am I happy to
stop? These questions, as well as the potential to recycle the developed
systems model for other purposes, will be addressed during this webinar using
the development of a systems pharmacology model for the cardiovascular effects
of S1P agonists as an example.