Webinar: Applying QSAR and PBPK Modeling to Bridge Discovery and Assessment of
Clinical Potential
Michael Bolger, Ph.D. and Ted Grasela, Ph.D.
Oct 19, 2016, 12:00 to 1:00 EDT
Abstract:
Mechanistic absorption and physiologically-based pharmacokinetic models play an
ever increasing role in assessing the clinical potential of compounds in
discovery, guiding the selection of lead compounds, and optimizing their
chances for commercial success. There are many important questions about how to
best develop and apply these models. What are the best sources of input
parameters: bottom up (in silico and in vitro) or top down (in vivo)? How
reliable are the simulation results? Should these models play a role in dose
estimation for First-in-Human (FIH) clinical studies? Can these be used for
regulatory submissions and potential biowaivers?
Register at http://www.rosaandco.com/webinar.html