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Dear all.
To estimate the PK parameters of an antibiotics and define the adequate dose
regimen is one of my
present woks.
Because of sparseness of data, I performed the PK analysis using prior
subroutine " NWPRI " in
NONMEM(ver 6). and then stabilized estimation of PK parameters could be
possible.
However, Wings for NONMEM, Perl-speaks NONMEM as front end of NONMEM did
not open or
read the text file including subroutine Prior.
I question whether this problem is a my own problem or general problem.
I wish to hear experiences of this problem.
Sincerly.
Thank you.
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Byung-Jin Ahn M.D.
Research Doctor
CMC Clinical Research Coordinating Center
College of Medicine, The Catholic University of Korea
505 Banpo-Dong, Seocho-Gu, Seoul 137-701, Korea
TEL: +82-2-590-4957 FAX: +82-2-590-7843
[EMAIL PROTECTED]
Using Prior subroutine
Byung-Jin,
The default NONMEM method puts all its output and run files in the same folder
as the control stream file. Experienced NONMEM users find this organization is
too simple which prevents such obvious things like running two NONMEM runs at
the same time from the same directory.
Both WFN and PSN create run-directories for NM-TRAN/NONMEM to do their work.
While this solves the problem of running several simultaneous runs and also
organizes the results more clearly (WFN) it brings its own problems for unusual
uses which require locating external files such as the PRIOR subroutine.
In your control stream you will have to specify a path to the PRIOR subroutine
file so that NM-TRAN can find it from the run-directory.
e.g. for WFN
$SUBR PRIOR=../prior.for
will look for prior.for in the same directory as the control stream file.
PSN has a much more complicated run-directory system and usually (but I dont
know for sure always) will need to look 2 levels higher e.g.
$SUBR PRIOR=../../prior.for
WFN (and most likely PSN) will let you use a full path to the file so that it
can be located anywhere you want e.g.
$SUBR PRIOR=X:/solarsystem/earth/newzealand/auckland/prior.for
Good luck.
Nick
Byung-Jin Ahn wrote:
>
> Dear all.
>
> To estimate the PK parameters of an antibiotics and define the adequate dose
> regimen is one of my
>
> present woks.
>
> Because of sparseness of data, I performed the PK analysis using prior
> subroutine " NWPRI " in
>
> NONMEM(ver 6). and then stabilized estimation of PK parameters could be
> possible.
>
> However, Wings for NONMEM, Perl-speaks NONMEM as front end of NONMEM did not
> open or
>
> read the text file including subroutine Prior.
>
> I question whether this problem is a my own problem or general problem.
>
> I wish to hear experiences of this problem.
>
> Sincerly.
>
> Thank you.
>
> Byung-Jin Ahn M.D.
>
> Research Doctor
> CMC Clinical Research Coordinating Center
> College of Medicine, The Catholic University of Korea
> 505 Banpo-Dong, Seocho-Gu, Seoul 137-701, Korea
> TEL: +82-2-590-4957 FAX: +82-2-590-7843
> [EMAIL PROTECTED] [Image]
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
www.health.auckland.ac.nz/pharmacology/staff/nholford
Hi Byung-Jin,
As an alternative to Nicks suggestions PsN can move additional files
into the actual run directory. You need to add the argument
"extra_files" and specify the file name. For example, using the tool
"execute":
execute run1.mod -extra_files=prior.for
where run1.mod is the name of the control stream and prior.for is the
name of the text file holding the NWPRI subroutine.
Good luck!
Jakob