In Rosa's next monthly webinar on Oct 24th at 1:pm EDT, Iraj Hosseini, the
scientist at Genentech who was one of the main drivers behind gPKPDSim, a
SimBiology-based GUI for PKPD modeling in drug development, will demonstrate
his app and show others how they can use it in their research.
Register for the free webinar at: https://lnkd.in/gQqiUGC
Abstract: Modeling and simulation is increasingly used in drug development to
characterize pharmacokinetic-pharmacodynamic (PKPD) relationships and support
various efforts such as target feasibility assessment, molecule selection,
human PK projection, and preclinical and clinical dose and schedule
determination.
While model development typically requires mathematical modeling expertise,
model exploration and simulations could in many cases be performed by
scientists in various disciplines to support the design, analysis and
interpretation of experimental studies. To this end, we have developed a
versatile graphical user interface (GUI) application to enable easy use of any
model constructed in SimBiology(r) to execute various common PKPD analyses.
The MATLAB(r)-based GUI application, called gPKPDSim, has a single screen
interface and provides functionalities including simulation, data fitting
(parameter estimation), population simulation (exploring the impact of
parameter variability on the outputs of interest), and non-compartmental PK
analysis. Further, gPKPDSim is a user-friendly tool with capabilities including
interactive visualization, exporting of results and generation of
presentation-ready figures. gPKPDSim was designed primarily for use in
preclinical and translational drug development, although broader applications
exist. gPKPDSim is a MATLAB(r)-based open-source application and is publicly
available to download from MATLAB(r) Central(tm). We illustrate the use and
features of gPKPDSim using multiple PKPD models to demonstrate the wide
applications of this tool in pharmaceutical sciences.