Hybrid Genetic Algorithm Approaches to Model Selection
Speaker: Robert Bies, Pharm.D. Ph.D
Associate Professor of Pharmaceutical Sciences,
Member Computational and Data Enabled Sciences Program
University at Buffalo, NY
Thursday, Oct 24, 2019, 12:00 to 1:00 pm EDT
Register for free at https://www.rosaandco.com/webinars
Abstract:
A newly implemented version of an established Genetic Algorithm based approach
using NONMEM with some modifications into an R-shiny package that provides the
same functionality with additional flexibility is presented.
Some refinements have been made in the selection process for evaluating models
compared with the original evolutionary algorithm. Several population analyses
using the updated algorithm are compared with results obtained using classical
stepwise approaches in xenograft tumor growth profiles and population
pharmacokinetic analyses