Too many PRED-generated items in $TABLE

Dear All, I am working on a PK model, that can be implemented using $PRED but requires the definition of many parameters. I need most of these parameters to be reported in the output table. Unfortunately, this is the recurrent error message that I get when I start the estimation: "AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. 314 MORE THAN 20 PRED-GENERATED ITEMS SPECIFIED FOR $TABLE, $SCAT." I have tried to split my list of parameters in one or two $TABLE statements (see below) but it does not change anything... $TABLE ID DOSE TIME DVID Y FAST CL V ALPH TK01 KA1 LAG1 KA2 KA3 ADLA ONEHEADER NOPRINT FILE=param.fit $TABLE ID DOSE TIME DVID Y FAST ECL EV EALP ELA1 ETK1 ETB1 ETK2 ELA2 ETB2 ETB3 ETB4 EADL ELA3 ETK3 ETB5 ONEHEADER NOPRINT FILE=eta.fit (ID, DOSE, TIME, DVID, and FAST are defined in the data file) I am using NONMEM 6 with the Wings for NONMEM interface (v 6.1.3). Any suggestion to report that many parameters would be welcome. Sebastien Bihorel SUNY at Buffalo

Dear Sébastien: You may be able to avoid this problem in the second $TABLE by adding NOAPPEND option because it will not include DV, PRED, RES, WRES at the end of the record. Best regards, Sam Liao > Dear All, > > I am working on a PK model, that can be implemented using $PRED but requires the definition of many parameters. I need most of these parameters to be reported in the output table. Unfortunately, this is the recurrent error message that I get when I start the estimation: > > "AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. > 314 MORE THAN 20 PRED-GENERATED ITEMS SPECIFIED FOR $TABLE, $SCAT." > > I have tried to split my list of parameters in one or two $TABLE statements (see below) but it does not change anything... > > $TABLE ID DOSE TIME DVID Y FAST CL V ALPH TK01 KA1 LAG1 KA2 KA3 ADLA > ONEHEADER NOPRINT > FILE=param.fit > $TABLE ID DOSE TIME DVID Y FAST ECL EV EALP ELA1 ETK1 ETB1 ETK2 ELA2 ETB2 > ETB3 ETB4 EADL ELA3 ETK3 ETB5 > ONEHEADER NOPRINT > FILE=eta.fit > > (ID, DOSE, TIME, DVID, and FAST are defined in the data file) > > I am using NONMEM 6 with the Wings for NONMEM interface (v 6.1.3). Any suggestion to report that many parameters would be welcome. > > Sebastien Bihorel > SUNY at Buffalo

With NONMEM VI 2.0, the number of pred-generated items listed in table or scatter will increase from 20 to 50. When NOAPPEND is specified, this will increase to 54. On Fri, 21 Mar 2008 16:05:22 -0400, "Sébastien Bihorel" <[EMAIL PROTECTED]> said: > Dear All, > > I am working on a PK model, that can be implemented using $PRED but > requires the definition of many parameters. I need most of these > parameters to be reported in the output table. Unfortunately, this is > the recurrent error message that I get when I start the estimation: > > "AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. > 314 MORE THAN 20 PRED-GENERATED ITEMS SPECIFIED FOR $TABLE, $SCAT." > > I have tried to split my list of parameters in one or two $TABLE > statements (see below) but it does not change anything... > > $TABLE ID DOSE TIME DVID Y FAST CL V ALPH TK01 KA1 LAG1 KA2 KA3 ADLA > ONEHEADER NOPRINT > FILE=param.fit > $TABLE ID DOSE TIME DVID Y FAST ECL EV EALP ELA1 ETK1 ETB1 ETK2 ELA2 ETB2 > ETB3 ETB4 EADL ELA3 ETK3 ETB5 > ONEHEADER NOPRINT > FILE=eta.fit > > (ID, DOSE, TIME, DVID, and FAST are defined in the data file) > > I am using NONMEM 6 with the Wings for NONMEM interface (v 6.1.3). Any > suggestion to report that many parameters would be welcome. > > Sebastien Bihorel > SUNY at Buffalo -- Alison Boeckmann [EMAIL PROTECTED]

Hi Sebastien, One solution is to just print out the first 20 items in the initial estimation, then run a second NONMEM run with the initial parameter estimates of that run set to the final parameter estimates of the first run. This second run should be run with MAXEVAL=0 in the $ESTIMATION section and can then contain the other table values you need. Cheers, Andy Andrew Hooker, Ph.D. Assistant Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Tel: +46 18 471 4355 www.farmbio.uu.se/research.php?avd=5

Dear All, Thanks for your help. > Sam : Indeed, I miscalculated the number of items in my second table. However, I tried to split them by invoking a third $TABLE and got the same error message. So, I believe NONMEM cannot extract more than 20 pred-generated items in total, should these items be split in 20 $TABLES or not. > Andrew, Satosh: I will try the tricks you described, thanks. > Alison: This evolution of NONMEM is a very good news ! Sebastien Sam Liao a écrit : > Dear Sébastien: > Sorry, this won't work since you already have 21 items in the second > $TABLE. I would try to separate it into two $TABLE and try to > combine the two after the run. > > Also like to recommend to follow the standard convention in $TABLE > files that are used in xpose to avoid this problem. > > Sam Liao > Pharmax Research >> Dear Sébastien: >> You may be able to avoid this problem in the second $TABLE by adding >> NOAPPEND option because it will not include DV, PRED, RES, WRES at >> the end of the record. >> >> Best regards, >> Sam Liao >>> Dear All, >>> >>> I am working on a PK model, that can be implemented using $PRED but >>> requires the definition of many parameters. I need most of these >>> parameters to be reported in the output table. Unfortunately, this >>> is the recurrent error message that I get when I start the estimation: >>> >>> "AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. >>> 314 MORE THAN 20 PRED-GENERATED ITEMS SPECIFIED FOR $TABLE, $SCAT." >>> >>> I have tried to split my list of parameters in one or two $TABLE >>> statements (see below) but it does not change anything... >>> >>> $TABLE ID DOSE TIME DVID Y FAST CL V ALPH TK01 KA1 LAG1 KA2 KA3 ADLA >>> ONEHEADER NOPRINT >>> FILE=param.fit >>> $TABLE ID DOSE TIME DVID Y FAST ECL EV EALP ELA1 ETK1 ETB1 ETK2 ELA2 >>> ETB2 >>> ETB3 ETB4 EADL ELA3 ETK3 ETB5 >>> ONEHEADER NOPRINT >>> FILE=eta.fit >>> >>> (ID, DOSE, TIME, DVID, and FAST are defined in the data file) >>> >>> I am using NONMEM 6 with the Wings for NONMEM interface (v 6.1.3). >>> Any suggestion to report that many parameters would be welcome. >>> >>> Sebastien Bihorel >>> SUNY at Buffalo >>> >>> >>> >> >> >> >> >> > > > >