Time 'T' in $Error

2 messages 2 people Latest: Jul 27, 2015

Time 'T' in $Error

From: Katrin Volz Date: July 27, 2015 technical
Dear NMuser, I would like to model a PD effect using a function which includes continuous time ‘ T ’. The PD Effect is coded in $Error. In general like this: $ERROR MyFunction = xxx + T PDEffect = Basline * MyFunction But ‘T’ cannot be used in $Error. I tried to code the function with ‘T’ in $DES and rename it to use it in $ERROR: $DES MyFunction = xxx + T $ERROR MyNewFunction = MyFunction PDEffect = Baseline * MyNewFunction but it didn’t worked (to rename was not permitted by NONMEM). Does anyone of you has an idea how to solve this problem? Thanks and best regards. Katrin Anke-Katrin Volz PhD Student Saarland University Clinical Pharmacy Campus C2 2 | Room 0.31 D- 66123 Saarbrücken mail [email protected] fon +49 [0]681 302 22 84 fax +49 [0]681 302 70 258 www.clinicalpharmacy.me

RE: Time 'T' in $Error

From: Bill Denney Date: July 27, 2015 technical
Hi Katrin, $ERROR is executed once per data row. The time when $ERROR is run is the TIME value (the discrete times of the measurement). For this specific example, you can just use TIME. You will need to code your $DES block so that what you're wanting to integrate as a function of time is in a compartment amount (e.g. A(1)). With your example, it's hard to see how T is used in the $DES, but perhaps you could share the real example to give a bit more concrete advice on how to integrate the answer into your code. Thanks, Bill
Quoted reply history
From: [email protected] [mailto:[email protected]] On Behalf Of Katrin Volz Sent: Monday, July 27, 2015 10:46 AM To: [email protected] Subject: [NMusers] Time 'T' in $Error Dear NMuser, I would like to model a PD effect using a function which includes continuous time ' T '. The PD Effect is coded in $Error. In general like this: $ERROR MyFunction = xxx + T PDEffect = Basline * MyFunction But 'T' cannot be used in $Error. I tried to code the function with 'T' in $DES and rename it to use it in $ERROR: $DES MyFunction = xxx + T $ERROR MyNewFunction = MyFunction PDEffect = Baseline * MyNewFunction but it didn't worked (to rename was not permitted by NONMEM). Does anyone of you has an idea how to solve this problem? Thanks and best regards. Katrin Anke-Katrin Volz PhD Student Saarland University Clinical Pharmacy Campus C2 2 | Room 0.31 D- 66123 Saarbrücken mail [email protected]<mailto:[email protected]> fon +49 [0]681 302 22 84 fax +49 [0]681 302 70 258 http://www.clinicalpharmacy.me