The University Hospital of Cologne
The Third Workshop on Non-Linear Mixed Effects Modeling using NONMEM® for
Beginners - 2017
We are delighted to announce our 3-day “Third Workshop to Non-Linear Mixed
Effects Modeling using NONMEM® for Beginners - 2017”. This workshop aims to
introduce the basic concepts and principles of non-linear mixed effects
modeling using NONMEM and other assisting software suites (e.g. PsN, Xpose &
Pirana). As part of the workshop, hands-on sessions and case studies will be
offered to familiarize the participants with the workflow and technicalities
associated with population modeling such as data management, model coding, and
interpretation of the results.
Target Audience: Pharmacometric analysis is progressively becoming an
indispensable tool in drug development and clinical care. The course is
intended for participants with limited or basic knowledge of PK/PD modeling who
wish to use this tool for informing and rationalizing decisions by introducing
them to some of the state-of-art tools in pharmacometrics.
Location: The University Hospital of Cologne, Center of Pharmacology, Cologne,
Germany.
Date: 30th June to 2nd July, 2017 (just after the 14th European ISSX meeting,
26th to 29th June, 2017,see http://issxeuro2017.org/ for details)
Instructors: The course will be organized by the Clinical Pharmacology Unit in
the University Hospital of Cologne, and tutored by young dynamic tutors (actual
and former members of the team) who have demonstrated their solid experience
and profound knowledge by numerous publications in international journals and
conferences. Through multiple research projects, they have used modeling and
simulation to address different questions relevant to drug development and to
the clinic. Examples of their work included analyzing data from different
sources (preclinical, phases-I, -II & -III studies), of different nature
(continuous, categorical and time-to-event), and for different purposes
(physiologically-based pharmacokinetics, mechanism-based pharmacodynamics, and
survival).
Language: English
Workshop Outline:
* Introduction to (non-)linear regression modeling: basic statistical
principles, least squares and maximum likelihood fitting, fixed and random
effects, first order (conditional) estimation.
* Introduction to population pharmacokinetic modeling: introduction to
NONMEM files (control stream and data file), structural model development,
random effects modeling.
* Model evaluation: introduction to supporting software tools (e.g. R,
Xpose, PsN), goodness-of-fit plots, residual diagnostics, bootstrapping
analysis, simulation based diagnostics (e.g. visual predictive checks).
* Covariate model building
* Introduction to modeling pharmacodynamics: different pharmacodynamic
models, linking pharmacokinetics to pharmacodynamics
Computers will not be provided and therefore we kindly ask you to bring your
own laptops with you and we will provide the necessary software on USB sticks.
Workshop Fees:
* 1200 € for participants from industry and commercial enterprises
* 600 € for academics and participants from non-profit organizations
* 300 € for students in MSc or PhD programs.
For registration: please send an e-mail to
[email protected]<mailto:[email protected]>; detailed information,
participation confirmation, and instructions for payment will follow as soon as
a sufficient number of participants is reached. Please DO NOT make any travel
arrangements before we send you back a confirmation.
Quoting some of the feedback from previous workshops:
“Instructors were experienced and well-informed. They were also patient with
questions”
“What I really liked about this workshop was the hands-on sessions”
“Material was excellent, and the tutors made an excellent introduction to
NONMEM”.
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Max Taubert
Department I of Pharmacology
Center for Pharmacology
Clinical Pharmacology Unit
University Hospital Cologne
Gleueler Str. 24, 50931 Köln, Germany
phone +49 221 478-86716
fax +49 221 478-7011
e-mail [email protected]<mailto:[email protected]>