Dear NMusers,
I wanted to pool IV bolus and 10-min infusion data and fit them together. My
question is how should I set up data item "RATE" for IV bolus? Should I leave
it blank for IV bolus (since RATE is needed for I.v. infusion)?
Any input is deeply appreciated.
Best,
Bei Yang
simultaneous fitting i.v. bolus and infusion data
Dear Bei Yang,
"RATE = 0" indicates that the dose is an instantaneous bolus dose.
Best regards,
Martin Bergstrand
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Pharmacometrics Research Group,
Department of Pharmaceutical Biosciences,
Uppsala University
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<mailto:[email protected]> [email protected]
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Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Bei Yang
Sent: Monday, January 10, 2011 8:43 PM
To: [email protected]
Subject: [NMusers] simultaneous fitting i.v. bolus and infusion data
Dear NMusers,
I wanted to pool IV bolus and 10-min infusion data and fit them together. My
question is how should I set up data item "RATE" for IV bolus? Should I
leave it blank for IV bolus (since RATE is needed for I.v. infusion)?
Any input is deeply appreciated.
Best,
Bei Yang
Hi Bei,
Bolus doses are indicated using RATE=0. You can use either a zero or a
blank in the field. I prefer the explicit zero to the implicit zero
(i.e. blank), but there should be no difference as far as NM-TRAN is
concerned.
Cheers... Brian
Quoted reply history
From: [email protected] [mailto:[email protected]]
On Behalf Of Bei Yang
Sent: Monday, January 10, 2011 2:43 PM
To: [email protected]
Subject: [NMusers] simultaneous fitting i.v. bolus and infusion data
Dear NMusers,
I wanted to pool IV bolus and 10-min infusion data and fit them
together. My question is how should I set up data item "RATE" for IV
bolus? Should I leave it blank for IV bolus (since RATE is needed for
I.v. infusion)?
Any input is deeply appreciated.
Best,
Bei Yang