Deal all
I am learning PKPD analysis using NONMEM. I want to simulate drug PK
using NONMEM and then compare the simulated to the measured results. I
prepared my model and data files as below and the $table adds DV,
PRED, RES &WRES. My challenge is the methods to use now so that i can
compare the simulated and the single timepoint concentration data.
$PROBLEM Simulation of population data
$INPUT ID TIME WT AMT DV GEN SEX AGE
$DATA prac2.csv IGNORE=@
$SUBROUTINE ADVAN1
$PK
CL=THETA(1)*EXP(ETA(1))
V=THETA(2)*EXP(ETA(2))
K=CL/V
S1=V
$ERROR
Y=F+F*EPS(1)
$THETA 10 250
$OMEGA .3 .3
$SIGMA .01
$SIMULATION (9215690) ; seed 1-7 digits
$TABLE ID TIME WT AMT GEN SEX AGE NOPRINT FILE=prac1 ONEHEADER
ID TIME DV GENE SEX AGE WT AMT
1 0 0 1 2 36 71 600
1 1.33 0 1 2 36 71 0
2 0 0 3 2 49 58 600
2 2 0 3 2 49 58 0
3 0 0 1 2 32 67 600
3 2.67 0 1 2 32 67 0
4 0 0 1 2 38 69 600
4 3 0 1 2 38 69 0
5 0 0 2 1 52 58 600
5 3.5 0 2 1 52 58 0
Bernard
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Bernard Ngara
Trainee Biostatistician
Africa Institute of Biomedical Science and Technology
P. O Box 2294
Harare
Zimbabwe
+263 772 160 896