$SIMULATION

From: Paul Hutson <prhutson@pharmacy.wisc.edu> Subject: $SIMULATION Date: Wed, 15 Aug 2001 14:50:41 -0500 Hi, all. I am seeking to simulate AUC-response relationships using $PRED, but without $PK, since there are no TIME points involved. After generating the simulated AUC-response (AUC, Effect) data, I would then evaluate them in one of two effect data analysis models. Several issues are confusing me: 1. In the SIMULATION 2 EXAMPLE, the generated table is described as having the "concatenated output of all the subproblems...". what does this mean, since I usually consider concatenation in FORTRAN to be a merging of strings? Are the DV or other simulated values in the TABLE some form of aggregate of the 10 repetitions? If not, where did the DVs from the iterations go? 2. What are the advantages of using SUBPROBLEMS=x as opposed to providing dummy "patient" IDs of 1..X? Thanks very much. Paul Paul Hutson, Pharm.D. Associate Professor (CHS) UW School of Pharmacy NOTE NEW ADDRESS effective 6/2001 777 Highland Avenue Madison, WI 53705-2222 Tel: (608) 263-2496 FAX: (608) 265-5421 Pager: (608) 265-7000, #7856

From: Nick Holford <n.holford@auckland.ac.nz> Subject: Re: $SIMULATION Date: Thu, 16 Aug 2001 08:23:56 +1200 Paul, Concatenated literally means chained together. With NONMEM this means: TABLE 1 results of subproblem 1 TABLE 1 results of subproblem 2 ... Advantage of using SUBPROBLEM is that you can easily select the number of replications without having to change the original data file template. Bottom line, just try it and look at the TABLE output... Nick -- Nick Holford, Divn Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.htm