Dear All
We are running a one-day Simcyp hands-on workshop on developing
population-PBPK driven PD/QSP (quantitative systems pharmacology) models
within its new integrated platform "Simcyp Designer". Attendees can get 3
Months Free Access to the 'QSP Designer': QSP Designer: Quantitative
systems pharmacology modeling with modular biological process map notation
and multiple language code generation - Matthews - 2023 - CPT:
Pharmacometrics & Systems Pharmacology - Wiley Online Library
https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/psp4.12972
The course reviews the fundamentals of PBPK and QSP modelling using the
Simcyp Simulator and builds rapidly to specialised applications where you
will modify existing PBPK models with your own PD/QSP extensions. We will
also examine the propagation of population variability to mechanistic
models of therapeutic effects dynamically interacting with drug
distribution models, as well as analysing population variability in
clinical data.
The key topics covered are:
*Latest advances of PBPK modelling using the Simcyp Simulator,
*Generation of realistic population variability using correlated Monte
Carlo sampling, covariate modeling withing the Simcyp Simulator,
*Replacing or modifying a tissular compartment within the Simcyp Simulator
with a user-defined model,
*Creating PD/QSP models using the Simcyp Designer's graphical editor,
*Incorporating physiological covariates within a user-defined mechanistic
effect model,
*Adding target mediated drug disposition (TMDD) processes to tissue
compartments, •Extending PBPK models for therapeutic proteins,
*Optimising PBPK models using data across different clinical trials
simultaneously.
To register please visit:
acop2024.eventscribe.net/aaStatic.asp?SFP=V0paTUFBRU5AMTkxMzM
Regards
Masoud