From:"Stefan Wilde"
Subject:[NMusers] Several metabolites in urine
Date:Mon, 27 May 2002 10:33:30 +0200
Dear all,
I have data for a substance and several metabolites that are measured in
plasma and urine.
Given 1 urine compartment, I could model it turning on/off and assigning DV
to the output compartment. But this doesn't work with more than one urine
compartment.
My problem is: How can I model different urine compartments using NMTran?
Thanks for your help
Stefan
Several metabolites in urine
From: "Joern Loetsch"
Subject:Re: [NMusers] Several metabolites in urine
Date:Mon, 27 May 2002 15:30:47 +0200
Dear Stefan,
You can model as many urine compartments as you need by using
differential equations with ADVAN6, possibly defining for each
metabolite a separate compartment. In the data set, you may need a CMT
column (CMT="compartment") where you state which compartment the actual
observation belongs to.
Regards
Jorn
______________________________________________________
Jorn Lotsch, MD
pharmazentrum frankfurt, Dept. of Clinical Pharmacology
Johann Wolfgang Goethe-University Hospital
Theodor-Stern-Kai 7
D-60590 Frankfurt am Main
GERMANY
Tel.:+49-69-6301-4589
Fax.:+49-69-6301-7636
http://www.klinik.uni-frankfurt.de/zpharm/klin/
From:Mats Karlsson
Subject:Re: [NMusers] Several metabolites in urine
Date:Mon, 27 May 2002 15:55:03 +0200
Dear Stefan,
If you have a linear model, you should also be able to use ADVAN5 or 7,
which may be a little faster.
Best regards,
Mats
Mats Karlsson, PhD
Professor of Pharmacometrics
Div. of Pharmacokinetics and Drug Therapy
Dept. of Pharmaceutical Biosciences
Faculty of Pharmacy
Uppsala University
Box 591
SE-751 24 Uppsala
Sweden
phone +46 18 471 4105
fax +46 18 471 4003
mats.karlsson@farmbio.uu.se