Second Announcement Fifth Pharmacometrics Network Benelux Meeting, Ghent, November 27th 2014

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Dear Colleagues, It is a pleasure to invite you to the fifth meeting of Pharmacometrics Network Benelux. Please mark the following date and time in your agenda: When: Thursday, November 27th - 12:00 - 18:00 Where: Het Pand - University Ghent, Onderbergen 1, 9000 Ghent, Belgium. Agenda theme: Physiologically Based Pharmacokinetic (PBPK) Modeling You can register by sending an e-mail to [email protected]<mailto:[email protected]> There is no registration fee, but registration is required for participation. The meeting will include a light lunch, a coffee/tea break and drinks upon closure. Scientific Program 12.00 - 13.30: Light lunch and welcome 13.30 - 14.30: An introduction to PBPK modeling: basic principles and fields of application Sieto Bosgra, TNO (The Netherlands) 14.30 - 15.00: A physiologically-based pharmacokinetic model to explore ALX-0171 PK in infants following inhalation Massimiliano Germani, Ablynx NV (Belgium) 15.00 - 15.30: Simulating Pharmacokinetics in Special Populations Lisa Almond, Simcyp (UK) 15.30 - 16.00: Coffee Break 16.00 - 16.30: Pharmacokinetics of midazolam and its metabolites after i.v. and oral administration in obese and non-obese patients Jantine Brussee, PhD student Leiden (The Netherlands) 16.30 - 17.00: The use of preclinical species in combination with PBPK modeling in selecting or ranking formulations for potential use in man An Van Den Bergh, Janssen (Belgium) 17.00 - 18.00 Closure and reception Venue Parking will be possible at the parking facility in front of Het Pand. Trains to Ghent Sint-Pieters station or Ghent South. From Ghent Sint-Pieters station take tram 1 (every 6 min) or 24 (every 20 min) to Korenmarkt. From Ghent South station take tram 4 (every 6 min) or 24 (every 20 min) or bus 17 (every 30 min) to Korenmarkt. We hope to see you in Ghent on November 27th!