Pharmacokineticist (ID: 42017)
Seattle Genetics is looking for a PK Scientist to join our Translational
Medicine Department
About Seattle Genetics
Seattle Genetics is a clinical stage biotechnology company focused on
the development and commercialization of monoclonal antibody-based
therapies for the treatment of cancer and autoimmune disease. The
company's lead product candidate, brentuximab vedotin (SGN-35), is in a
pivotal trial under a Special Protocol Assessment (SPA) with the FDA.
Brentuximab vedotin is empowered by Seattle Genetics' proprietary ADC
technology comprising highly potent synthetic drugs and stable linkers
for attaching the drugs to monoclonal antibodies. In addition, Seattle
Genetics has three other product candidates in ongoing clinical trials:
dacetuzumab (SGN-40), lintuzumab (SGN-33) and SGN-70. Dacetuzumab is
being developed under a worldwide collaboration with Genentech (a
wholly-owned member of the Roche Group). Seattle Genetics has
collaborations for its ADC technology with a number of leading
biotechnology and pharmaceutical companies. More information can be
found at www.seattlegenetics.com.
Major Duties & Responsibilities:
- Advance the science of novel antibody-based drug candidates through
the design, analysis, and interpretation of clinical and non-clinical
pharmacokinetic (PK) and pharmacokinetic/pharmacodynamic (PK/PD)
studies.
- Aid in the development of novel drug candidates by preparing PK,
PK/PD, popPK, and/or modeling and simulation components of study
protocols, reports, project summaries, development plans, and regulatory
submissions.
- Collaborate with drug development teams by serving as a key contact
for PK and PK/PD related issues and providing the PK and PK/PD
perspective of drug candidates.
Requirements:
- Advanced degree (Ph.D., Pharm. D., and/or M.S.) in Biomedical,
Biological or Pharmaceutical Science/Engineering with 0-3 years of
industry and/or related post-doctoral experience.
- In depth knowledge of PK and PK/PD concepts with a strong clinical
pharmacology background.
- Proficiency in PK and PK/PD analysis using WinNonLin or equivalent
software is a pre-requisite.
- Excellent oral and written communication skills and a proven track
record of working effectively in a dynamic, collaborative, team-oriented
setting.
Desired:
- Previous experience with monoclonal antibodies and/or cytotoxic
compounds is a plus.
- Experience with population PK/PD analysis using NONMEM or equivalent
software is a plus.
- Knowledge of regulatory requirements and experience in communications
with regulatory authorities in form of written summaries is desired.
To apply for this position, please visit:
http://ats.staffxl.com/ATS/PortalViewRequirement.do?reqGK=42017