scm problem

3 messages 2 people Latest: May 28, 2015

scm problem

From: Muhammad Usman Date: May 27, 2015 technical
Dear NMUsers I am a beginner with NONMEM. I have developed a model and want to use AGE, WT, CRCL, SeCR and SEX as covariates on CL, V1 and V2. Can someone provide me the step by step guidence how can I perform this Analysis by using Pirana? Regards -- *Muhammad Usman* PhD Scholar Westfälische Wilhelms-Universität Münster Institut für Pharmazeutische und Medizinische Chemie - Klinische Pharmazie - Corrensstrasse 48 48149 Münster Room No. A120.209 Phone: +49 251/8332171 Mob # +49 176 70962067

Re: scm problem

From: Ron Keizer Date: May 27, 2015 technical
hi Muhammad, a brief guidance on how to do a stepwise covariate search with PsN+Pirana is given in our recent tutorial in CPT-PSP ( http://onlinelibrary.wiley.com/doi/10.1038/psp.2013.24/abstract), in which we used the scm tool in PsN, and Pirana to generate the scm config file. Let me know if you don't get the example to run. (Someone reported recently that the appendix files were not available anymore, but they are also here: https://github.com/ronkeizer/ppx_tutorial) Of course—if you keep having trouble getting the scm tool to run—you could choose to implement and run the covariate models manually: for only five covariates there is only little gain in using the scm tool. A gentle introduction on how to build covariate models in NONMEM is available in chapter 5.7 of the recent book by Owen and Fiedler-Kelly ( http://www.amazon.com/Introduction-Population-Pharmacokinetic-Pharmacodynamic-Nonlinear/dp/0470582294/ ). best regards, Ron PS. any Pirana-specific questions can also be posted at http://qa.piranasoftware.com
Quoted reply history
On Wed, May 27, 2015 at 6:35 AM, Muhammad Usman <[email protected]> wrote: > Dear NMUsers > I am a beginner with NONMEM. I have developed a model and want to use AGE, > WT, CRCL, SeCR and SEX as covariates on CL, V1 and V2. Can someone provide > me the step by step guidence how can I perform this Analysis by using > Pirana? > > Regards > > -- > *Muhammad Usman* > PhD Scholar > Westfälische Wilhelms-Universität Münster > Institut für Pharmazeutische und Medizinische Chemie > - Klinische Pharmazie - > Corrensstrasse 48 > 48149 Münster > > Room No. A120.209 > > Phone: +49 251/8332171 > > Mob # +49 176 70962067 >

Re: scm problem

From: Muhammad Usman Date: May 28, 2015 technical
Dear Ron, Thank you very much for your guidence. I have gone through this tutorial and now I understand the process for scm. Regards
Quoted reply history
On 28 May 2015 at 01:06, Ron Keizer <[email protected]> wrote: > hi Muhammad, > > a brief guidance on how to do a stepwise covariate search with PsN+Pirana > is given in our recent tutorial in CPT-PSP ( > http://onlinelibrary.wiley.com/doi/10.1038/psp.2013.24/abstract), in > which we used the scm tool in PsN, and Pirana to generate the scm config > file. Let me know if you don't get the example to run. (Someone reported > recently that the appendix files were not available anymore, but they are > also here: https://github.com/ronkeizer/ppx_tutorial) > > Of course—if you keep having trouble getting the scm tool to run—you > could choose to implement and run the covariate models manually: for only > five covariates there is only little gain in using the scm tool. A gentle > introduction on how to build covariate models in NONMEM is available in > chapter 5.7 of the recent book by Owen and Fiedler-Kelly ( > http://www.amazon.com/Introduction-Population-Pharmacokinetic-Pharmacodynamic-Nonlinear/dp/0470582294/ > ). > > best regards, > Ron > > PS. any Pirana-specific questions can also be posted at > http://qa.piranasoftware.com > > > On Wed, May 27, 2015 at 6:35 AM, Muhammad Usman <[email protected]> > wrote: > >> Dear NMUsers >> I am a beginner with NONMEM. I have developed a model and want to use >> AGE, WT, CRCL, SeCR and SEX as covariates on CL, V1 and V2. Can someone >> provide me the step by step guidence how can I perform this Analysis by >> using Pirana? >> >> Regards >> >> -- >> *Muhammad Usman* >> PhD Scholar >> Westfälische Wilhelms-Universität Münster >> Institut für Pharmazeutische und Medizinische Chemie >> - Klinische Pharmazie - >> Corrensstrasse 48 >> 48149 Münster >> >> Room No. A120.209 >> >> Phone: +49 251/8332171 >> >> Mob # +49 176 70962067 >> > > -- *Muhammad Usman* PhD Scholar Westfälische Wilhelms-Universität Münster Institut für Pharmazeutische und Medizinische Chemie - Klinische Pharmazie - Corrensstrasse 48 48149 Münster Room No. A120.209 Phone: +49 251/8332171 Mob # +49 176 70962067